NUMBL Antikörper

Produktnummer ABIN7117092

Dieses Anti-NUMBL-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von NUMBL in WB, ELISA und IHC. Geeignet für Human.

Kurzübersicht für NUMBL Antikörper (ABIN7117092)

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NUMBL Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Klon: 8E0

Produktdetails anti-NUMBL Antikörper

Verwendungszweck: NUMBL antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: numb homolog(Drosophila)-like

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu NUMBL

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Andere Bezeichnung: NUMBL

Hintergrund:

Synonyms: Numb-like protein|Numb-related protein (Numb-R)|NUMBL

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Molekulargewicht: 70 kDa

Gen-ID: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization