NGEF Antikörper
Kurzübersicht für NGEF Antikörper (ABIN7116830)
Target
Alle NGEF Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Verwendungszweck
- NGEF antibody
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Aufreinigung
- Immunogen affinity purified
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Reinheit
- ≥95 % as determined by SDS-PAGE
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Immunogen
- neuronal guanine nucleotide exchange factor
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Isotyp
- IgG
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Applikationshinweise
- WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:50-1:500
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freeze / thaw cycles.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- -20°C for 12 months
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Haltbarkeit
- 12 months
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- NGEF (Neuronal Guanine Nucleotide Exchange Factor (NGEF))
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Andere Bezeichnung
- NGEF
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Hintergrund
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Synonyms: Ephexin-1|Eph-interacting exchange protein|Neuronal guanine nucleotide exchange factor|NGEF
Background: Acts as a guanine nucleotide exchange factor(GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension(By similarity).
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Molekulargewicht
- 75 kDa
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Gen-ID
- 25791
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UniProt
- Q8N5V2
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Pathways
- Neurotrophin Signalübertragung
Target
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