MMS19 Antikörper

Produktnummer ABIN7116477

Der Maus Monoklonal anti-MMS19 Antikörper (Klon 6H1) (ABIN7116477) detektiert spezifisch MMS19 in WB, ELISA, IF und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für MMS19 Antikörper (ABIN7116477)

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MMS19 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Klon: 6H1

Produktdetails anti-MMS19 Antikörper

Verwendungszweck: MMS19 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: MMS19 nucleotide excision repair homolog

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu MMS19

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Andere Bezeichnung: MMS19

Hintergrund:

Synonyms: MMS19 nucleotide excision repair protein homolog (hMMS19)|MET18 homolog|MMS19-like protein|MMS19|MMS19L

Background: Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Molekulargewicht: 103 kDa

Gen-ID: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding