MUL1 Antikörper

Produktnummer ABIN7116330

Dieses Anti-MUL1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MUL1 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MUL1 Antikörper (ABIN7116330)

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MUL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MUL1 Antikörper

Verwendungszweck: MUL1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: mitochondrial E3 ubiquitin ligase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu MUL1

Target: MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase 1 (MUL1))

Andere Bezeichnung: MUL1

Hintergrund:

Synonyms: Mitochondrial ubiquitin ligase activator of NFKB 1|E3 SUMO-protein ligase MUL1|E3 ubiquitin-protein ligase MUL1|Growth inhibition and death E3 ligase|Mitochondrial-anchored protein ligase|Protein Hades|Putative NF-kappa-B-activating protein 266|RING finger protein 218|RING-type E3 ubiquitin transferase NFKB 1|MUL1|C1orf166|GIDE|MAPL|MULAN|RNF218

Background: Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its ability to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

Molekulargewicht: 35 kDa

Gen-ID: 79594

UniProt: Q969V5

Pathways: Positive Regulation of Endopeptidase Activity