MAP4K6 Antikörper (AA 1-304)

Produktnummer ABIN7116324

Dieses Anti-MAP4K6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MAP4K6 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MAP4K6 Antikörper (AA 1-304) (ABIN7116324)

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP4K6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-MAP4K6 Antikörper

Bindungsspezifität: AA 1-304

Verwendungszweck: MINK1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-304aa

Immunogen: misshapen-like kinase 1(zebrafish)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu MAP4K6

Target: MAP4K6 (MINK1) (Misshapen-Like Kinase 1 (MINK1))

Andere Bezeichnung: MINK1

Hintergrund:

Synonyms: Misshapen-like kinase 1|GCK family kinase MiNK|MAPK/ERK kinase kinase kinase 6 (MEK kinase kinase 6, MEKKK 6)|Misshapen/NIK-related kinase|Mitogen-activated protein kinase kinase kinase kinase 6|MINK1|B55|MAP4K6|MINK|YSK2|ZC3

Background: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration.

Molekulargewicht: 150 kDa

Gen-ID: 50488

UniProt: Q8N4C8

Pathways: Synaptic Membrane