MACF1 Antikörper

Produktnummer ABIN7116291

Dieses Anti-MACF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MACF1 in ELISA, IHC und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für MACF1 Antikörper (ABIN7116291)

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MACF1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-MACF1 Antikörper

Verwendungszweck: MACF1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: microtubule-actin crosslinking factor 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu MACF1

Target: MACF1 (Microtubule-Actin Crosslinking Factor 1 (MACF1))

Andere Bezeichnung: MACF1

Hintergrund:

Synonyms: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5|620 kDa actin-binding protein (ABP620)|Actin cross-linking family protein 7|Macrophin-1|Trabeculin-alpha|MACF1|ABP620|ACF7|KIAA0465|KIAA0754|KIAA1251

Background: Isoform 2 is a F-actin-binding protein which may play a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex(composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane. Has actin-regulated ATPase activity and is essential for controlling focal adhesions(FAs) assembly and dynamics. May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4. Plays a key role in wound healing and epidermal cell migration. Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate MT dynamics and polarize hair follicle stem cells(By similarity).

Molekulargewicht: 83 kDa

Gen-ID: 23499

UniProt: Q9UPN3