METAP2 Antikörper

Produktnummer ABIN7116239

Der Kaninchen Polyklonal Anti-METAP2-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, METAP2 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für METAP2 Antikörper (ABIN7116239)

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser METAP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-METAP2 Antikörper

Verwendungszweck: METAP2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: methionyl aminopeptidase 2

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu METAP2

Target: METAP2 (Methionyl Aminopeptidase 2 (METAP2))

Andere Bezeichnung: METAP2

Hintergrund:

Synonyms: Methionine aminopeptidase 2 (MAP 2, MetAP 2)|Initiation factor 2-associated 67 kDa glycoprotein (p67, p67eIF2)|Peptidase M|METAP2|MNPEP|P67EIF2

Background: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged(Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.

Molekulargewicht: 67 kDa

Gen-ID: 10988

UniProt: P50579

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling