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MARK2 Antikörper

Dieses Anti-MARK2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MARK2 in WB, ELISA, IHC und IP. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7116060

Kurzübersicht für MARK2 Antikörper (ABIN7116060)

Target

Alle MARK2 Antikörper anzeigen
MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

Reaktivität

  • 77
  • 53
  • 44
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 73
  • 3
  • 1
Kaninchen

Klonalität

  • 65
  • 12
Polyklonal

Konjugat

  • 37
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MARK2 Antikörper ist unkonjugiert

Applikation

  • 46
  • 32
  • 16
  • 16
  • 11
  • 10
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    MAP/microtubule affinity-regulating kinase 2

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))

    Andere Bezeichnung

    MARK2

    Hintergrund

    Synonyms:EMK1 Background:Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins(DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

    Molekulargewicht

    77-90 kDa

    Gen-ID

    2011

    UniProt

    Q7KZI7

    Pathways

    SARS-CoV-2 Protein Interaktom, Phosphorylierungen bei SARS-CoV-2 Infektion
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