IFITM3 Antikörper (AA 1-133)

Produktnummer ABIN7115388

Dieses Anti-IFITM3-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IFITM3 in WB, ELISA, IHC, IF und FACS. Geeignet für Human.

Kurzübersicht für IFITM3 Antikörper (AA 1-133) (ABIN7115388)

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IFITM3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS)

Klon: 5H4

Produktdetails anti-IFITM3 Antikörper

Bindungsspezifität: AA 1-133

Verwendungszweck: IFITM3 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-133aa

Immunogen: IFITM2/3 fusion protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu IFITM3

Target: IFITM3 (Interferon-Induced Transmembrane Protein 3 (IFITM3))

Andere Bezeichnung: IFITM3

Hintergrund:

Synonyms: Interferon-induced transmembrane protein 3|Dispanin subfamily A member 2b (DSPA2b)|Interferon-inducible protein 1-8U|IFITM3

Background: IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus(SARS-CoV), Marburg virus(MARV) and Ebola virus(EBOV), Dengue virus(DNV), West Nile virus(WNV), human immunodeficiency virus type 1(HIV-1) and vesicular stomatitis virus(VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase(v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization and is also required for the function of the v-ATPase to lower the pH in phagocytic endosomes thus establishing an antiviral state.This antibody recognizes both IFITM2 and IFITM3.

Molekulargewicht: 14 kDa

Gen-ID: 10410

UniProt: Q01628