Importin 11 Antikörper

Produktnummer ABIN7115208

Dieser Anti-Importin 11-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von Importin 11 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für Importin 11 Antikörper (ABIN7115208)

Target: Importin 11 (IPO11)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Importin 11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-Importin 11 Antikörper

Verwendungszweck: IPO11 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: importin 11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu Importin 11

Target: Importin 11 (IPO11)

Andere Bezeichnung: IPO11

Hintergrund:

Synonyms: Importin-11 (Imp11)|Ran-binding protein 11 (RanBP11)|IPO11|RANBP11

Background: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity). Mediates the nuclear import of UBE2E3, and of RPL12(By similarity).

Molekulargewicht: 112 kDa

Gen-ID: 51194

UniProt: Q9UI26

Pathways: Protein targeting to Nucleus