HSD17B10 Antikörper (AA 1-261)

Produktnummer ABIN7115148

Dieses Anti-HSD17B10-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von HSD17B10 in WB und ELISA. Geeignet für Human und Maus.

Kurzübersicht für HSD17B10 Antikörper (AA 1-261) (ABIN7115148)

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HSD17B10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 6C4

Produktdetails anti-HSD17B10 Antikörper

Bindungsspezifität: AA 1-261

Verwendungszweck: HSD17B10 antibody

Aufreinigung: Protein A+G purification

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-261aa

Immunogen: hydroxysteroid(17-beta) dehydrogenase 10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:1000-1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu HSD17B10

Target: HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))

Andere Bezeichnung: HSD17B10

Hintergrund:

Synonyms: 3-hydroxyacyl-CoA dehydrogenase type-2|17-beta-estradiol 17-dehydrogenase|2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD)|3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))|3-hydroxy-2-methylbutyryl-CoA dehydrogenase|3-hydroxyacyl-CoA dehydrogenase type II|3alpha(or 20beta)-hydroxysteroid dehydrogenase|7-alpha-hydroxysteroid dehydrogenase|Endoplasmic reticulum-associated amyloid beta-peptide-binding protein|Mitochondrial ribonuclease P protein 2 (Mitochondrial RNase P protein 2)|Short chain dehydrogenase/reductase family 5C member 1|Short-chain type dehydrogenase/reductase XH98G2|Type II HADH|HSD17B10|ERAB|HADH2|MRPP2|SCHAD|SDR5C1|XH98G2

Background: Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. Catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease(AD).

Molekulargewicht: 27 kDa

Gen-ID: 3028

UniProt: Q99714