HEY1 Antikörper

Produktnummer ABIN7114852

Produktdetails anti-HEY1 Antikörper

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HEY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: hairy/enhancer-of-split related with YRPW motif 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu HEY1

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Andere Bezeichnung: HEY1 (HEY1 Produkte)

Synonyme: BHLHb31 antikoerper, CHF2 antikoerper, HERP2 antikoerper, HESR1 antikoerper, HRT-1 antikoerper, OAF1 antikoerper, AI316788 antikoerper, AI414254 antikoerper, HRT1 antikoerper, Herp2 antikoerper, Hesr1 antikoerper, bHLHb31 antikoerper, hesr-1 antikoerper, id:ibd1292 antikoerper, zgc:110572 antikoerper, bc8 antikoerper, chf2 antikoerper, herp2 antikoerper, hesr1 antikoerper, hrt1 antikoerper, oaf1 antikoerper, xbc8 antikoerper, hes related family bHLH transcription factor with YRPW motif 1 antikoerper, hairy/enhancer-of-split related with YRPW motif 1 antikoerper, hes-related family bHLH transcription factor with YRPW motif 1 antikoerper, hes related family bHLH transcription factor with YRPW motif 1 S homeolog antikoerper, HEY1 antikoerper, Hey1 antikoerper, hey1 antikoerper, hey1.S antikoerper

Hintergrund: Synonyms:BHLHB31, CHF2, HERP2, HESR1, HRT1 Background:Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).

Molekulargewicht: 33 kDa

Gen-ID: 23462

UniProt: Q9Y5J3

Pathways: Tube Formation