HEY1 Antikörper

Produktnummer ABIN7114852

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch HEY1 in WB, ELISA, IHC und IP. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für HEY1 Antikörper (ABIN7114852)

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HEY1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-HEY1 Antikörper

Verwendungszweck: HEY1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: hairy/enhancer-of-split related with YRPW motif 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu HEY1

Target: HEY1 (Ha-Ry/enhancer-of-Split Related with YRPW Motif 1 (HEY1))

Andere Bezeichnung: HEY1

Hintergrund:

Synonyms: Hairy/enhancer-of-split related with YRPW motif protein 1|Cardiovascular helix-loop-helix factor 2 (CHF-2)|Class B basic helix-loop-helix protein 31 (bHLHb31)|HES-related repressor protein 1|Hairy and enhancer of split-related protein 1 (HESR-1)|Hairy-related transcription factor 1 (HRT-1, hHRT1)|HEY1|BHLHB31|CHF2|HERP2|HESR1|HRT1

Background: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'(PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3(PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal(PubMed:25985737).

Molekulargewicht: 33 kDa

Gen-ID: 23462

UniProt: Q9Y5J3

Pathways: Tube Formation