GRB7 Antikörper

Produktnummer ABIN7114786

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GRB7 in WB, ELISA und IP. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für GRB7 Antikörper (ABIN7114786)

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRB7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Produktdetails anti-GRB7 Antikörper

Verwendungszweck: GRB7 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: growth factor receptor-bound protein 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu GRB7

Target: GRB7 (Growth Factor Receptor-Bound Protein 7 (GRB7))

Andere Bezeichnung: GRB7

Hintergrund:

Synonyms: Growth factor receptor-bound protein 7|B47|Epidermal growth factor receptor GRB-7|GRB7 adapter protein|GRB7

Background: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress(By similarity).

Molekulargewicht: 60-70 kDa

Gen-ID: 2886

UniProt: Q14451

Pathways: EGFR Signaling Pathway, Ribonucleoprotein Complex Subunit Organization