BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) Antikörper

Produktnummer ABIN7114081

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in WB, IHC, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1) Antikörper (ABIN7114081)

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails

Verwendungszweck: ABRAXAS1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: family with sequence similarity 175, member A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2400, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Antigendetails

Target: BRCA1-A Complex Subunit Abraxas 1 (ABRAXAS1)

Andere Bezeichnung: ABRAXAS1

Hintergrund:

Synonyms: BRCA1-A complex subunit Abraxas 1|Coiled-coil domain-containing protein 98|Protein FAM175A|ABRAXAS1|ABRA1|CCDC98|FAM175A

Background: Involved in DNA damage response and double-strand break(DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Molekulargewicht: 46 kDa

Gen-ID: 84142

UniProt: Q6UWZ7