SUPT16H Antikörper

Produktnummer ABIN7114058

Der Kaninchen Polyklonal Anti-SUPT16H-Antikörper wurde für ELISA, WB, IHC und IP validiert. Er ist geeignet, SUPT16H in Proben von Human und Maus zu detektieren.

Kurzübersicht für SUPT16H Antikörper (ABIN7114058)

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUPT16H Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-SUPT16H Antikörper

Verwendungszweck: SUPT16H antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: suppressor of Ty 16 homolog

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu SUPT16H

Target: SUPT16H (FACT complex subunit SPT16 (SUPT16H))

Andere Bezeichnung: SUPT16H

Hintergrund:

Synonyms: FACT complex subunit SPT16|Chromatin-specific transcription elongation factor 140 kDa subunit|FACT 140 kDa subunit|FACTp140|Facilitates chromatin transcription complex subunit SPT16 (hSPT16)|SUPT16H|FACT140|FACTP140

Background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2(casein kinase II).

Molekulargewicht: 140 kDa

Gen-ID: 6830

UniProt: Q9Y5B9

Pathways: Chromatin Binding