FBXO9 Antikörper
Kurzübersicht für FBXO9 Antikörper (ABIN7114056)
Target
Alle FBXO9 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Aufreinigung
- Immunogen affinity purified
-
Reinheit
- ≥95 % as determined by SDS-PAGE
-
Immunogen
- F-box protein 9
-
Isotyp
- IgG
-
-
anti-F-Box Protein 9 (FBXO9) (AA 13-111) antibody
FBXO9 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 338-447) antibodyFBXO9 Reaktivität: Human ELISA, IHC (p) Wirt: Maus Monoclonal 1G12 unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 1-437) antibodyFBXO9 Reaktivität: Human WB, IF Wirt: Maus Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (Middle Region) antibodyFBXO9 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Pferd, Schwein, Kaninchen, Meerschweinchen, Saccharomyces cerevisiae WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) antibodyFBXO9 Reaktivität: Human, Maus, Ratte WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 346-373), (C-Term) antibodyFBXO9 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB26852 unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 179-228) antibodyFBXO9 Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Huhn, Pferd, Schwein, Kaninchen, Fledermaus WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-F-Box Protein 9 (FBXO9) (AA 346-373), (C-Term) antibodyFBXO9 Reaktivität: Human, Maus WB, FACS Wirt: Kaninchen Polyclonal unconjugated
-
-
Applikationshinweise
- WB: 1:500-1:2000, IHC: 1:20-1:200
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Format
- Liquid
-
Buffer
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
-
Konservierungsmittel
- Sodium azide
-
Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Lagerung
- -20 °C
-
Informationen zur Lagerung
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
-
Haltbarkeit
- 12 months
-
-
- FBXO9 (F-Box Protein 9 (FBXO9))
-
Andere Bezeichnung
- FBXO9
-
Hintergrund
- Synonyms:FBX9, VCIA1 Background:Substrate recognition component of a SCF(SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.
-
Molekulargewicht
- 52 kDa
-
Gen-ID
- 26268
-
UniProt
- Q9UK97
Target
-
