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FBXW5 Antikörper

Dieses Anti-FBXW5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FBXW5 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN7114041

Kurzübersicht für FBXW5 Antikörper (ABIN7114041)

Target

Alle FBXW5 Antikörper anzeigen
FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reaktivität

  • 34
  • 16
  • 16
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 32
  • 2
Kaninchen

Klonalität

  • 34
Polyklonal

Konjugat

  • 11
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser FBXW5 Antikörper ist unkonjugiert

Applikation

  • 30
  • 13
  • 11
  • 4
  • 2
  • 2
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Aufreinigung

    Immunogen affinity purified

    Reinheit

    ≥95 % as determined by SDS-PAGE

    Immunogen

    F-box and WD repeat domain containing 5

    Isotyp

    IgG
  • Applikationshinweise

    WB: 1:500-1:2000, IHC: 1:20-1:200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

    Haltbarkeit

    12 months
  • Target

    FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

    Andere Bezeichnung

    FBXW5

    Hintergrund

    Synonyms:FBW5 Background:Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.

    Molekulargewicht

    65 kDa

    Gen-ID

    54461

    UniProt

    Q969U6
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