FBXW5 Antikörper

Produktnummer ABIN7114041

Dieses Anti-FBXW5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von FBXW5 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für FBXW5 Antikörper (ABIN7114041)

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FBXW5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FBXW5 Antikörper

Verwendungszweck: FBXW5 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: F-box and WD repeat domain containing 5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu FBXW5

Target: FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))

Andere Bezeichnung: FBXW5

Hintergrund:

Synonyms: F-box/WD repeat-containing protein 5|F-box and WD-40 domain-containing protein 5|FBXW5|FBW5

Background: Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway.

Molekulargewicht: 65 kDa

Gen-ID: 54461

UniProt: Q969U6