EYA2 Antikörper

Produktnummer ABIN7114029

Dieses Anti-EYA2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EYA2 in WB, ELISA und IHC. Geeignet für Human, Ratte und Maus.

Kurzübersicht für EYA2 Antikörper (ABIN7114029)

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EYA2 Antikörper

Verwendungszweck: EYA2 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: eyes absent homolog 2(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu EYA2

Target: EYA2 (Eyes Absent Homolog 2 (Drosophila) (EYA2))

Andere Bezeichnung: EYA2

Hintergrund:

Synonyms: Eyes absent homolog 2|EYA2|EAB1

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2, in this it is functionally redundant with EYA1(PubMed:12500905).

Molekulargewicht: 57 kDa

Gen-ID: 2139

UniProt: O00167