EYA1 Antikörper

Produktnummer ABIN7114028

Der Kaninchen Polyklonal Anti-EYA1-Antikörper wurde für WB, ELISA, IHC und IF validiert. Er ist geeignet, EYA1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für EYA1 Antikörper (ABIN7114028)

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EYA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-EYA1 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: eyes absent homolog 1(Drosophila)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu EYA1

Target: EYA1 (Eyes Absent Homolog 1 (EYA1))

Andere Bezeichnung: EYA1

Hintergrund: Synonyms: Background:Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5(By similarity). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX(H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress(PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis(By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues(in vitro)(By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears(By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2(By similarity).

Molekulargewicht: 60 kDa ,50 kDa

Gen-ID: 2138

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus