EXD1 Antikörper

Produktnummer ABIN7114002

Dieses Anti-EXD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von EXD1 in WB, IF, ELISA und IHC. Geeignet für Human, Ratte und Maus.

Kurzübersicht für EXD1 Antikörper (ABIN7114002)

Target: EXD1 (Exonuclease 3'-5' Domain Containing 1 (EXD1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EXD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-EXD1 Antikörper

Verwendungszweck: EXD1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: exonuclease 3'-5' domain containing 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IHC: 1:50-1:500, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu EXD1

Target: EXD1 (Exonuclease 3'-5' Domain Containing 1 (EXD1))

Andere Bezeichnung: EXD1

Hintergrund:

Synonyms: piRNA biogenesis protein EXD1|Exonuclease 3'-5' domain-containing protein 1|Exonuclease 3'-5' domain-like-containing protein 1|Inactive exonuclease EXD1|EXD1|EXDL1

Background: RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity(By similarity). The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease(By similarity).

Molekulargewicht: 36 kDa

Gen-ID: 161829

UniProt: Q8NHP7