EHD3 Antikörper

Produktnummer ABIN7113755

Der Kaninchen Polyklonal Anti-EHD3-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, EHD3 in Proben von Human und Maus zu detektieren.

Kurzübersicht für EHD3 Antikörper (ABIN7113755)

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EHD3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-EHD3 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: EH-domain containing 3

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu EHD3

Target: EHD3 (EH-Domain Containing 3 (EHD3))

Andere Bezeichnung: EHD3

Hintergrund: Synonyms:EHD2, Background:ATP-and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis(PubMed:25686250). In vitro causes tubulation of endocytic membranes(PubMed:24019528). Binding to phosphatidic acid induces its membrane tubulation activity(By similarity). Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment(ERC), retrograde early endosome to Golgi, and endosome to plasma membrane(rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology(PubMed:16251358, PubMed:17233914, PubMed:19139087, PubMed:23781025). Involved in the recycling of internalized D1 dopamine receptor(PubMed:21791287). Plays a role in cardiac protein trafficking probably implicating ANK2(PubMed:20489164). Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction(By similarity). In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function(By similarity). Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance(PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing(By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis, possibly sharing redundant functions with EHD1(PubMed:25686250).

Molekulargewicht: 61 kDa

Gen-ID: 30845

UniProt: Q9NZN3