DNAJC10 Antikörper

Produktnummer ABIN7113582

Dieses Anti-DNAJC10-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DNAJC10 in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für DNAJC10 Antikörper (ABIN7113582)

Target: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJC10 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-DNAJC10 Antikörper

Verwendungszweck: DNAJC10 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: DnaJ(Hsp40) homolog, subfamily C, member 10

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu DNAJC10

Target: DNAJC10 (DnaJ (Hsp40) Homolog, Subfamily C, Member 10 (DNAJC10))

Andere Bezeichnung: DNAJC10

Hintergrund:

Synonyms: DnaJ homolog subfamily C member 10|Endoplasmic reticulum DNA J domain-containing protein 5 (ER-resident protein ERdj5, ERdj5)|Macrothioredoxin (MTHr)|DNAJC10|ERDJ5

Background: Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation(ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.

Molekulargewicht: 75-80 kDa

Gen-ID: 54431

UniProt: Q8IXB1

Pathways: Cell RedoxHomeostasis