DOCK7 Antikörper

Produktnummer ABIN7113381

Dieses Anti-DOCK7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DOCK7 in ELISA, WB und IP. Geeignet für Human, Ratte und Maus.

Kurzübersicht für DOCK7 Antikörper (ABIN7113381)

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DOCK7 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-DOCK7 Antikörper

Verwendungszweck: DOCK7 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: dedicator of cytokinesis 7

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IP: 1:500-1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu DOCK7

Target: DOCK7 (Dedicator of Cytokinesis 7 (DOCK7))

Andere Bezeichnung: DOCK7

Hintergrund:

Synonyms: Dedicator of cytokinesis protein 7|DOCK7|KIAA1771

Background: Functions as a guanine nucleotide exchange factor(GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization(PubMed:16982419). Has a role in pigmentation(By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells(RGCs) proliferation versus differentiation, negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3(By similarity).Multiple isoforms of DOCK 7 exist due to alternative splicing events. This DOCK 7 antibody can recognize all the isoforms.

Molekulargewicht: 240 kDa

Gen-ID: 85440

UniProt: Q96N67