DHX36 Antikörper

Produktnummer ABIN7113365

Der Kaninchen Polyklonal Anti-DHX36-Antikörper wurde für WB, ELISA, IHC und IP validiert. Er ist geeignet, DHX36 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für DHX36 Antikörper (ABIN7113365)

Target: DHX36 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DHX36 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-DHX36 Antikörper

Verwendungszweck: DHX36 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: DEAH(Asp-Glu-Ala-His) box polypeptide 36

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu DHX36

Target: DHX36 (DEAH (Asp-Glu-Ala-His) Box Polypeptide 36 (DHX36))

Andere Bezeichnung: DHX36

Hintergrund:

Synonyms: ATP-dependent DNA/RNA helicase DHX36|DEAD/H box polypeptide 36|DEAH-box protein 36|G4-resolvase-1 (G4R1)|MLE-like protein 1|RNA helicase associated with AU-rich element protein|DHX36|DDX36|KIAA1488|MLEL1|RHAU

Background: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component(TERC) 5'-end(nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation, the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification.

Molekulargewicht: 120 kDa

Gen-ID: 170506

UniProt: Q9H2U1

Pathways: Toll-Like Receptors Cascades