CPEB1 Antikörper

Produktnummer ABIN7113294

Der Kaninchen Polyklonal anti-CPEB1 Antikörper (ABIN7113294) detektiert spezifisch CPEB1 in WB, ELISA und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CPEB1 Antikörper (ABIN7113294)

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CPEB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-CPEB1 Antikörper

Verwendungszweck: CPEB1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: cytoplasmic polyadenylation element binding protein 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CPEB1

Target: CPEB1 (Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1))

Andere Bezeichnung: CPEB1

Hintergrund:

Synonyms: Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1, CPE-binding protein 1, h-CPEB, hCPEB-1)|CPEB1|CPEB

Background: Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element(CPE), an uridine-rich sequence element(consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA, a repression that is relieved by phosphorylation or degradation(By similarity). Involved in the transport of CPE-containing mRNA to dendrites, those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses(By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation(By similarity). Induces the assembly of stress granules in the absence of stress.

Molekulargewicht: 54 kDa

Gen-ID: 64506

UniProt: Q9BZB8

Pathways: Synaptic Membrane