CC2D1A Antikörper

Produktnummer ABIN7112928

Dieses Anti-CC2D1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CC2D1A in WB, IHC, ELISA und IF. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CC2D1A Antikörper (ABIN7112928)

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CC2D1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-CC2D1A Antikörper

Verwendungszweck: CC2D1A antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: coiled-coil and C2 domain containing 1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CC2D1A

Target: CC2D1A (Coiled-Coil and C2 Domain Containing 1A (CC2D1A))

Andere Bezeichnung: CC2D1A

Hintergrund:

Synonyms: Coiled-coil and C2 domain-containing protein 1A|Akt kinase-interacting protein 1|Five prime repressor element under dual repression-binding protein 1 (FRE under dual repression-binding protein 1, Freud-1)|Putative NF-kappa-B-activating protein 023N|CC2D1A|AKI1

Background: Transcription factor that binds specifically to the DRE(dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses(By similarity). Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

Molekulargewicht: 130 kDa, 104 kDa

Gen-ID: 54862

UniProt: Q6P1N0