CHMP6 Antikörper

Produktnummer ABIN7112649

Dieses Anti-CHMP6-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHMP6 in WB und ELISA. Geeignet für Human, Maus und Ratte.

Kurzübersicht für CHMP6 Antikörper (ABIN7112649)

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CHMP6 Antikörper

Verwendungszweck: CHMP6 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: chromatin modifying protein 6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CHMP6

Target: CHMP6 (Charged Multivesicular Body Protein 6 (CHMP6))

Andere Bezeichnung: CHMP6

Hintergrund:

Synonyms: Charged multivesicular body protein 6|Chromatin-modifying protein 6|Vacuolar protein sorting-associated protein 20 (Vps20, hVps20)|CHMP6|VPS20

Background: Probable core component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes.

Molekulargewicht: 28-30 kDa

Gen-ID: 79643

UniProt: Q96FZ7