CHMP1A Antikörper

Produktnummer ABIN7112643

Dieses Anti-CHMP1A-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CHMP1A in WB, ELISA, IHC und IP. Geeignet für Human und Maus.

Kurzübersicht für CHMP1A Antikörper (ABIN7112643)

Target: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CHMP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-CHMP1A Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: chromatin modifying protein 1A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:1000, IP: 1:500-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu CHMP1A

Target: CHMP1A (Charged Multivesicular Body Protein 1A (CHMP1A))

Andere Bezeichnung: CHMP1A

Hintergrund: Synonyms:CHMP1, CHMP1A, chromatin modifying protein 1A, hVps46 1, KIAA0047, PCOLN3, PRSM1, Vps46 1 Background:Probable peripherally associated component of the endosomal sorting required for transport complex III(ESCRT-III) which is involved in multivesicular bodies(MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles(ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O,-I,-II and-III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses(HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group(PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Molekulargewicht: 33 kDa, 25 kDa

Gen-ID: 5119

UniProt: Q9HD42