CNOT1 Antikörper

Produktnummer ABIN7112432

Der Kaninchen-Polyklonal Anti-CNOT1-Antikörper wurde für ELISA, WB, IHC und IP validiert. Er ist geeignet zum Nachweis von CNOT1 in Proben aus Human, Maus und Ratte. }

Kurzübersicht für CNOT1 Antikörper (ABIN7112432)

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CNOT1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-CNOT1 Antikörper

Verwendungszweck: CNOT1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: CCR4-NOT transcription complex, subunit 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CNOT1

Target: CNOT1 (CCR4-NOT Transcription Complex, Subunit 1 (CNOT1))

Andere Bezeichnung: CNOT1

Hintergrund:

Synonyms: CCR4-NOT transcription complex subunit 1|CCR4-associated factor 1|Negative regulator of transcription subunit 1 homolog (NOT1H, hNOT1)|CNOT1|CDC39|KIAA1007|NOT1

Background: Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element(ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem(ES) cell identity.

Molekulargewicht: 240-250 kDa, 174 kDa

Gen-ID: 23019

UniProt: A5YKK6

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Stem Cell Maintenance