CBLC Antikörper

Produktnummer ABIN7112417

Der Kaninchen Polyklonal Anti-CBLC-Antikörper wurde für WB und ELISA validiert. Er ist geeignet, CBLC in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für CBLC Antikörper (ABIN7112417)

Target: CBLC (Cbl proto-oncogene C (CBLC))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBLC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CBLC Antikörper

Verwendungszweck: CBLC antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: Cas-Br-M(murine) ecotropic retroviral transforming sequence c

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu CBLC

Target: CBLC (Cbl proto-oncogene C (CBLC))

Andere Bezeichnung: CBLC

Hintergrund:

Synonyms: E3 ubiquitin-protein ligase CBL-C|RING finger protein 57|RING-type E3 ubiquitin transferase CBL-C|SH3-binding protein CBL-3|SH3-binding protein CBL-C|Signal transduction protein CBL-C|CBLC|CBL3|RNF57

Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.

Molekulargewicht: 52 kDa

Gen-ID: 23624

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway