BVES Antikörper

Produktnummer ABIN7112013

Dieser Anti-BVES-Antikörper ist ein Kaninchen-Polyklonal-Antikörper zum Nachweis von BVES in WB, ELISA und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für BVES Antikörper (ABIN7112013)

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BVES Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-BVES Antikörper

Verwendungszweck: BVES antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: blood vessel epicardial substance

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:100-1:1000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu BVES

Target: BVES (Blood Vessel Epicardial Substance (BVES))

Andere Bezeichnung: BVES

Hintergrund:

Synonyms: Blood vessel epicardial substance (hBVES)|Popeye domain-containing protein 1 (Popeye protein 1)|BVES|POP1|POPDC1

Background: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction(TJ) paracellular permeability barrier in epithelial cells(PubMed:16188940). Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading(By similarity). Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density(PubMed:26642364). Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.

Molekulargewicht: 41-70 kDa

Gen-ID: 11149

UniProt: Q8NE79