BHLHE22 Antikörper

Produktnummer ABIN7111942

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch BHLHE22 in WB, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für BHLHE22 Antikörper (ABIN7111942)

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BHLHE22 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Produktdetails anti-BHLHE22 Antikörper

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: basic helix-loop-helix family, member e22

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:1000, IF: 1:10-1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Haltbarkeit: 12 months

Details zu BHLHE22

Target: BHLHE22 (Basic Helix-Loop-Helix Family, Member E22 (BHLHE22))

Andere Bezeichnung: BHLHE22

Hintergrund: Synonyms:BHLHB5, TNRC20 Background:Inhibits DNA binding of TCF3/E47 homodimers and TCF3(E47)/NEUROD1 heterodimers and acts as a strong repressor of Neurod1 and Myod-responsive genes, probably by heterodimerization with class a basic helix-loop-helix factors. Despite the presence of an intact basic domain, does not bind to DNA(By similarity). In the brain, may function as an area-specific transcription factor that regulates the postmitotic acquisition of area identities and elucidate the genetic hierarchy between progenitors and postmitotic neurons driving neocortical arealization. May be required for the survival of a specific population of inhibitory neurons in the superficial laminae of the spinal chord dorsal horn that may regulate pruritis. Seems to play a crucial role in the retinogenesis, in the specification of amacrine and bipolar subtypes. Forms with PRDM8 a transcriptional repressor complex controlling genes involved in neural development and neuronal differentiation.

Molekulargewicht: 37 kDa

Gen-ID: 27319

UniProt: Q8NFJ8