ANKRD15 Antikörper

Produktnummer ABIN7111596

Dieses Anti-ANKRD15-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ANKRD15 in WB, ELISA, IF und IHC. Geeignet für Human, Maus und Ratte.

Kurzübersicht für ANKRD15 Antikörper (ABIN7111596)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANKRD15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Produktdetails anti-ANKRD15 Antikörper

Verwendungszweck: KANK1 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: KN motif and ankyrin repeat domains 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Andere Bezeichnung: KANK1

Hintergrund:

Synonyms: KN motif and ankyrin repeat domain-containing protein 1|Ankyrin repeat domain-containing protein 15|Kidney ankyrin repeat-containing protein|KANK1|ANKRD15|KANK|KIAA0172

Background: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Molekulargewicht: 150 kDa

Gen-ID: 23189

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization