alpha KGDHC Antikörper

Produktnummer ABIN7111489

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch alpha KGDHC in WB, IHC, ELISA und IF. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.

Kurzübersicht für alpha KGDHC Antikörper (ABIN7111489)

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser alpha KGDHC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-alpha KGDHC Antikörper

Verwendungszweck: OGDH antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu alpha KGDHC

Target: alpha KGDHC (alphaKGDHC) (alpha Ketoglutarate Dehydrogenase (alphaKGDHC))

Andere Bezeichnung: OGDH

Hintergrund:

Synonyms: 2-oxoglutarate dehydrogenase complex component E1 (E1o, OGDC-E1, OGDH-E1)|2-oxoglutarate dehydrogenase, mitochondrial|Alpha-ketoglutarate dehydrogenase (Alpha-KGDH-E1)|Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase|OGDH

Background: This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Molekulargewicht: 116 kDa

Gen-ID: 4967

UniProt: Q02218