ALKBH7 Antikörper

Produktnummer ABIN7111484

Der Kaninchen Polyklonal Anti-ALKBH7-Antikörper wurde für WB, ELISA und IHC validiert. Er ist geeignet, ALKBH7 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ALKBH7 Antikörper (ABIN7111484)

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALKBH7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-ALKBH7 Antikörper

Verwendungszweck: ALKBH7 antibody

Aufreinigung: Immunogen affinity purified

Reinheit: ≥95 % as determined by SDS-PAGE

Immunogen: alkB, alkylation repair homolog 7(E. coli)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:200-1:2000, IHC: 1:20-1:200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze / thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: -20°C for 12 months

Haltbarkeit: 12 months

Details zu ALKBH7

Target: ALKBH7 (AlkB, Alkylation Repair Homolog 7 (ALKBH7))

Andere Bezeichnung: ALKBH7

Hintergrund:

Synonyms: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial|Alkylated DNA repair protein alkB homolog 7|Spermatogenesis cell proliferation-related protein|Spermatogenesis-associated protein 11|ALKBH7|ABH7|SPATA11

Background: May function as protein hydroxylase, can catalyze auto-hydroxylation at Leu-110(in vitro), but this activity may be due to the absence of the true substrate(PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death(PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage(PubMed:23666923). Does not display DNA demethylase activity(PubMed:23666923). Involved in fatty acid metabolism(By similarity).

Molekulargewicht: 25 kDa

Gen-ID: 84266

UniProt: Q9BT30