Dieses Anti-AKR1C4-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von AKR1C4 in WB, ELISA und IF. Geeignet für Human, Maus und Ratte.
AKR1C4
Reaktivität: Human
ELISA, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:1000-1:10000, IF: 1:10-1:100
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Informationen zur Lagerung
-20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Haltbarkeit
12 months
Target
AKR1C4
(Aldo-keto Reductase Family 1 Member C4 (AKR1C4))
Andere Bezeichnung
AKR1C4
Hintergrund
Synonyms:AKR1C4, HAKRA, CHDR, 3 alpha HSD1, Chlordecone reductase Background:Catalyzes the transformation of the potent androgen dihydrotestosterone(DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol(3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone(kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.