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AJUBA Antikörper

AJUBA Reaktivität: Human, Maus, Ratte WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN7111418
  • Target Alle AJUBA Antikörper anzeigen
    AJUBA (Ajuba LIM Protein (AJUBA))
    Reaktivität
    • 13
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 9
    • 3
    • 1
    Kaninchen
    Klonalität
    • 12
    • 1
    Polyklonal
    Konjugat
    • 10
    • 1
    • 1
    • 1
    Dieser AJUBA Antikörper ist unkonjugiert
    Applikation
    • 8
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Aufreinigung
    Immunogen affinity purified
    Reinheit
    ≥95 % as determined by SDS-PAGE
    Immunogen
    jub, ajuba homolog
    Isotyp
    IgG
    Top Product
    Discover our top product AJUBA Primärantikörper
  • Applikationshinweise
    WB: 1:200-1:2000, IHC: 1:20-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
    Haltbarkeit
    12 months
  • Target
    AJUBA (Ajuba LIM Protein (AJUBA))
    Andere Bezeichnung
    Ajuba (AJUBA Produkte)
    Synonyme
    JUB antikoerper, Jub antikoerper, ajuba LIM protein antikoerper, AJUBA antikoerper, Ajuba antikoerper
    Hintergrund
    Synonyms:Ajuba, JUB, Protein ajuba Background:Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA(miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1.
    Molekulargewicht
    57 kDa
    Gen-ID
    84962
    UniProt
    Q96IF1
    Pathways
    Chromatin Binding, Cell-Cell Junction Organization
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