MACC1 Antikörper (AA 761-852)

Produktnummer ABIN706526

Es sind 6+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-MACC1 Antikörper wird verwendet zum Nachweis von MACC1 in Proben von Human und Ratte. Er wurde validiert für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro).

Kurzübersicht für MACC1 Antikörper (AA 761-852) (ABIN706526)

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MACC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-MACC1 Antikörper

Bindungsspezifität: AA 761-852

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MACC1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-MACC1 Antikörper (ABIN706526)

Shi, Song, Wang, Zhang, Zheng: "MACC‑1 antibody target therapy suppresses growth and migration of non‑small cell lung cancer." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 7329-7336, (2017) (PubMed).

Montorsi, Guizzetti, Alecci, Caporali, Martello, Atene, Parenti, Pizzini, Zanovello, Bortoluzzi, Ferrari, Grande, Zanocco-Marani: "Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1." in: Oncotarget, Vol. 7, Issue 37, pp. 59144-59157, (2016) (PubMed).

Sun, Li, Dai, Tan, Zhao, Li, Wang: "Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells." in: Molecular medicine reports, Vol. 12, Issue 3, pp. 3423-31, (2015) (PubMed).

Li, Zhang, Zhao, Shi, Yao, Zhang, Guo, Liu: "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." in: Oncology letters, Vol. 9, Issue 5, pp. 1989-1996, (2015) (PubMed).

Guo, Yang, Yao, Zhang, Da, Duan: "Expression of MACC1 and c-Met in human gastric cancer and its clinical significance." in: Cancer cell international, Vol. 13, Issue 1, pp. 121, (2013) (PubMed).

Details zu MACC1

Target: MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Andere Bezeichnung: MACC1

Hintergrund:

Synonyms: 7A5, SH3BP4L, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1

Background: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

Gen-ID: 346389

UniProt: Q6ZN28