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MACC1 Antikörper (AA 761-852)

Der Kaninchen Polyklonal Anti-MACC1-Antikörper wurde für WB, ELISA, IF (cc), IF (p), IHC (p) und IHC (fro) validiert. Er ist geeignet, MACC1 in Proben von Human und Ratte zu detektieren. Es sind 6+ Publikationen verfügbar.
Produktnummer ABIN706526

Kurzübersicht für MACC1 Antikörper (AA 761-852) (ABIN706526)

Target

Alle MACC1 Antikörper anzeigen
MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

Reaktivität

  • 38
  • 17
  • 5
Human, Ratte

Wirt

  • 37
  • 1
Kaninchen

Klonalität

  • 36
  • 2
Polyklonal

Konjugat

  • 14
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser MACC1 Antikörper ist unkonjugiert

Applikation

  • 28
  • 12
  • 12
  • 11
  • 9
  • 5
  • 5
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 761-852

    Kreuzreaktivität

    Human, Ratte

    Homologie

    Mouse,Cow

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human MACC1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Shi, Song, Wang, Zhang, Zheng: "MACC‑1 antibody target therapy suppresses growth and migration of non‑small cell lung cancer." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 7329-7336, (2017) (PubMed).

    Montorsi, Guizzetti, Alecci, Caporali, Martello, Atene, Parenti, Pizzini, Zanovello, Bortoluzzi, Ferrari, Grande, Zanocco-Marani: "Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1." in: Oncotarget, Vol. 7, Issue 37, pp. 59144-59157, (2016) (PubMed).

    Sun, Li, Dai, Tan, Zhao, Li, Wang: "Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells." in: Molecular medicine reports, Vol. 12, Issue 3, pp. 3423-31, (2015) (PubMed).

    Li, Zhang, Zhao, Shi, Yao, Zhang, Guo, Liu: "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." in: Oncology letters, Vol. 9, Issue 5, pp. 1989-1996, (2015) (PubMed).

    Guo, Yang, Yao, Zhang, Da, Duan: "Expression of MACC1 and c-Met in human gastric cancer and its clinical significance." in: Cancer cell international, Vol. 13, Issue 1, pp. 121, (2013) (PubMed).

  • Target

    MACC1 (Metastasis Associated in Colon Cancer 1 (MACC1))

    Andere Bezeichnung

    MACC1

    Hintergrund

    Synonyms: 7A5, SH3BP4L, Metastasis-associated in colon cancer protein 1, SH3 domain-containing protein 7a5, MACC1

    Background: Acts as a transcription activator for MET and as a key regulator of HGF-MET signaling. Promotes cell motility, proliferation and hepatocyte growth factor (HGF)-dependent scattering in vitro and tumor growth and metastasis in vivo.

    Gen-ID

    346389

    UniProt

    Q6ZN28
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