ITGA4 Antikörper (HRP)

Produktnummer ABIN7091260

Der Kaninchen Polyklonal Anti-ITGA4-Antikörper wurde für WB validiert. Er ist geeignet, ITGA4 in Proben von Human, Maus und Ratte zu detektieren.

Kurzübersicht für ITGA4 Antikörper (HRP) (ABIN7091260)

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITGA4 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB)

Produktdetails anti-ITGA4 Antikörper (HRP)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin alpha 4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Details zu ITGA4

Target: ITGA4 (Integrin alpha 4 (ITGA4))

Andere Bezeichnung: Integrin alpha 4

Hintergrund:

Synonyms: Alpha 4 subunit of VLA 4 receptor,ITG-_4: Antigen CD49D, CD 49d , CD49d, CD49d antigen, CDw49d, IA4, Integrin alpha IV, ITGA 4, ITGA4, LPAM23, MGC90518, Very Late Activation Antigen 4, Very Late Activation Protein 4 Receptor Alpha 4 Subunit, VLA 4, VLA4, integrin alpha-4, ITA4_HUMAN,

Background: Integrin alpha 4 (also called CD49d) is a 150 kDa protein that possesses a large extracellular domain involved in ligand binding, a single transmembrane domain, and an intracellular regulatory domain possessing multiple sites for phosphorylation. Integrin alpha 4 forms heterodimers with integrins beta 1 and beta 7. Integrin alpha 4 is expressed on leukocytes and leukocyte precursors, neural crest cells, and developing skeletal muscles and is essential for embryogenesis, hematopoiesis, and immune responses. The presence of integrin alpha 4 promotes cell migration and inhibits cell spreading and contractility. Integrin alpha 4 function has been implicated in the pathogenesis of multiple diseases including asthma, rheumatoid arthritis, Crohn's disease, ulcerative colitis, hepatitis C, and multiple sclerosis, and therefore, modulation of integrin alpha 4 function has become an important target for drug discovery.

Gen-ID: 3676

UniProt: P13612

Pathways: Integrin Complex