ANKRD15 Antikörper

Produktnummer ABIN7090750

Der Maus Monoklonal Anti-ANKRD15-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, ANKRD15 in Proben von Human zu detektieren.

Kurzübersicht für ANKRD15 Antikörper (ABIN7090750)

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ANKRD15 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: Y6S1

Produktdetails anti-ANKRD15 Antikörper

Homologie: Human

Immunogen: Recombinant human KANK1.

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu ANKRD15

Target: ANKRD15 (Ankyrin Repeat Domain 15 (ANKRD15))

Andere Bezeichnung: KANK1

Hintergrund:

Synonyms: ANKRD 15, Ankyrin repeat domain 15, Ankyrin repeat domain containing protein 15, Ankyrin repeat domain-containing protein 15, DKFZp451G231, KANK, KANK1_HUMAN, KIAA0172, Kidney ankyrin repeat containing protein, Kidney ankyrin repeat-containing protein, KN motif and ankyrin repeat domain-containing protein 1, MGC43128.

Background: Involved in the control of cytoskeleton formation by regulating actin polymerization. Inhibits actin fiber formation and cell migration. Inhibits RhoA activity, the function involves phosphorylation through PI3K/Akt signaling and may depend on the competetive interaction with 14-3-3 adapter proteins to sequester them from active complexes. Inhibits the formation of lamellipodia but not of filopodia, the function may depend on the competetive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading, the function is partially mediated by BAIAP2. Inhibits neurite outgrowth. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. In the nucleus, is involved in beta-catenin-dependent activation of transcription. Potential tumor suppressor for renal cell carcinoma.

Gen-ID: 23189

UniProt: Q14678

Pathways: Regulation of Actin Filament Polymerization