PHD1 Antikörper (AA 321-407)

Produktnummer ABIN705896

Produktdetails anti-PHD1 Antikörper

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Bindungsspezifität: AA 321-407

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PHD1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Cow,Sheep

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PHD1/prolyl hydroxylase

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu PHD1

Target: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Andere Bezeichnung: PHD1 (EGLN2 Produkte)

Synonyme: egln2 antikoerper, phd2 antikoerper, PHD1 antikoerper, 0610011A13Rik antikoerper, C85656 antikoerper, Hif-p4h-1 antikoerper, Ier4 antikoerper, Phd1 antikoerper, SM-20 antikoerper, HIF-PH1 antikoerper, HPH-1 antikoerper, HPH-3 antikoerper, PHD-1 antikoerper, EIT6 antikoerper, HIFPH1 antikoerper, egl-9 family hypoxia-inducible factor 1 antikoerper, egl-9 family hypoxia inducible factor 2 antikoerper, Egl nine homolog 2 antikoerper, egl-9 family hypoxia-inducible factor 2 L homeolog antikoerper, egl-9 family hypoxia-inducible factor 2 antikoerper, egln1 antikoerper, EGLN2 antikoerper, egln2 antikoerper, egln2.L antikoerper, Egln2 antikoerper

Hintergrund:

Synonyms: Egl nine homolog 2, prolyl hydroxylase,EGLN 2, EGLN2, EIT 6, EIT6, H P4H 1, H PH1, HPH1, HPH 3, HPH3, P4H1, PHD 1, PHD1, EGL nine C.elegans homolog 2, EGLN2_HUMAN.

Background: PHD1 catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins and hydroxylates HIF-1 alpha at Pro-402 and Pro-564, and HIF-2 alpha. It functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. It may play a role in cell growth regulation.

Gen-ID: 112398

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis