Sphingomyelin Synthase 1 Antikörper (AA 331-413) (Cy5)

Produktnummer ABIN705375

Dieses Anti-Sphingomyelin Synthase 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Sphingomyelin Synthase 1 in WB, IF (cc) und IF (p). Geeignet für Maus.

Kurzübersicht für Sphingomyelin Synthase 1 Antikörper (AA 331-413) (Cy5) (ABIN705375)

Target: Sphingomyelin Synthase 1 (SGMS1)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Sphingomyelin Synthase 1 Antikörper ist konjugiert mit Cy5

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-Sphingomyelin Synthase 1 Antikörper (Cy5)

Bindungsspezifität: AA 331-413

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Sphingomyelin Synthase 1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Sphingomyelin Synthase 1

Target: Sphingomyelin Synthase 1 (SGMS1)

Andere Bezeichnung: Sphingomyelin Synthase 1

Hintergrund:

Synonyms: MOB, MOB1, SMS1, TMEM23, hmob33, Phosphatidylcholine:ceramide cholinephosphotransferase 1, Medulla oblongata-derived protein, Protein Mob, Sphingomyelin synthase 1, Transmembrane protein 23, SGMS1

Background: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

Gen-ID: 259230

UniProt: Q86VZ5

Pathways: Cellular Response to Molecule of Bacterial Origin