WDR81 Antikörper

Produktnummer ABIN7076221

Der Kaninchen Polyklonal anti-WDR81 Antikörper (ABIN7076221) detektiert spezifisch WDR81 in WB, IHC und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für WDR81 Antikörper (ABIN7076221)

Target: WDR81 (WD Repeat Domain 81 (WDR81))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WDR81 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-WDR81 Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse WDR81

Anwendungsinformationen

Applikationshinweise: WB (H,M,R) 1:1000- 1:2000, IHC/IF (M,R) 1:700-1:1400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu WDR81

Target: WDR81 (WD Repeat Domain 81 (WDR81))

Andere Bezeichnung: WDR81

Hintergrund: This gene functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C (By similarity). May also be involved in maintenance of normal mitochondrial structure and organization.

Molekulargewicht: 65 kDa

Gen-ID: 192652

NCBI Accession: NP_620400

UniProt: Q5ND34