UAP1L1 Antikörper
Kurzübersicht für UAP1L1 Antikörper (ABIN7076143)
Target
Reaktivität
Wirt
Klonalität
Konjugat
Applikation
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Aufreinigung
- Affinity purification
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Immunogen
- Recombinant protein corresponding to Mouse UAP1L1
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Applikationshinweise
- WB (M) 1:2000- 1:4000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Buffer
- PBS, pH 7.4, 0.02 % sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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- UAP1L1 (UDP-N-Acteylglucosamine Pyrophosphorylase 1-Like 1 (UAP1L1))
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Andere Bezeichnung
- UAP1L1
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Hintergrund
- UAP1 is a 56KDa isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a alpha/beta structure resembling the Rossmann fold. Northern Blot analysis detected abundant expression of UAP1 in testis and sperm with a low expression in placenta, muscle and liver. It is implicated in antibody-mediated infertility in males.
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Molekulargewicht
- 57 kDa
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Gen-ID
- 227620
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NCBI Accession
- NP_001028465
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UniProt
- Q3TW96
Target
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