UBR5
Reaktivität: Maus
ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
IHC/IF (M,R) 1:350-1:700
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
UBR5
(Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5))
Andere Bezeichnung
EDD
Hintergrund
UBR5, also named as ubiquitin protein ligase E3 component n-reconin5, is a HECT domain-containing protein as a myocardin-binding protein. UBR5 is highly conserved in metazoans, has unique structural features, and has been implicated in regulation of DNA damage response, metabolism, transcription, and apoptosis. Hence, UBR5 is a key regulator of cell signaling relevant to broad areas of cancer biology . The human UBR5 gene has 59 exons, encoding an approximately 10kb mRNA and >300 kDa protein with widespread expression in various cell types.