TBC1D7 Antikörper

Produktnummer ABIN7075849

Dieses Anti-TBC1D7-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von TBC1D7 in WB. Geeignet für Human, Maus und Ratte.

Kurzübersicht für TBC1D7 Antikörper (ABIN7075849)

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBC1D7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TBC1D7 Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse TBC1D7

Anwendungsinformationen

Applikationshinweise: WB (H,M,R) 1: 500- 1: 1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TBC1D7

Target: TBC1D7 (TBC1 Domain Family, Member 7 (TBC1D7))

Andere Bezeichnung: TBC1D7

Hintergrund: TBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2/Bub2/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) . TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 . Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1. Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling . Mutations in the corresponding TBC1D7 gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania.

Molekulargewicht: 36 kDa

Gen-ID: 67046

NCBI Accession: NP_001239568

UniProt: Q9D0K0