Der Kaninchen Polyklonal anti-Sarcomeric alpha Actinin Antikörper (ABIN7075510) detektiert spezifisch Sarcomeric alpha Actinin in WB, IEM, IF und IHC.
Dieser Antikörper reagiert spezifisch mit Proben aus Maus und Ratte.
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
Sarcomeric alpha Actinin
Hintergrund
The primary function of alpha-actinin 2 is to crosslink filamentous actin molecules and titin molecules from adjoining sarcomeres at Z-discs, a function that is modulated by phospholipids. It is clear from studies by Hampton etal. that this crosslinking can assume a variety of conformations, with preferences for 60° and 120° angles. Alpha-actinin 2 also functions in docking signaling molecules at Z-discs, and additional studies have also implicated alpha-actinin 2 in the binding of cardiac ion channels, Kv1.5 in particular.