Der Kaninchen Polyklonal Anti-ARHGAP17-Antikörper wurde für WB, IF und IHC validiert. Er ist geeignet, ARHGAP17 in Proben von Ratte und Maus zu detektieren.
ARHGAP17
Reaktivität: Human
WB, ELISA, IHC
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB (M) 1:250-1:500, IHC/IF (R) 1:500-1:1500
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS, pH 7.4, 0.02 % sodium azide
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Target
ARHGAP17
(rho GTPase Activating Protein 17 (ARHGAP17))
Andere Bezeichnung
ARHGAP17
Hintergrund
ARHGAP17 is a Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. It specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. RHGAP17 participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1.