Chloride Channel 5 Antikörper

Produktnummer ABIN7073471

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Chloride Channel 5 in IHC und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für Chloride Channel 5 Antikörper (ABIN7073471)

Target: Chloride Channel 5 (CLCN5)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Chloride Channel 5 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Chloride Channel 5 Antikörper

Kreuzreaktivität: Human, Ratte

Aufreinigung: Affinity purification

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ClC-5

Anwendungsinformationen

Applikationshinweise: IHC/IF (H,M,R) 1:100-1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu Chloride Channel 5

Target: Chloride Channel 5 (CLCN5)

Andere Bezeichnung: ClC-5

Hintergrund: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport and maintain cellular volume.Mutations in the gene encoding CLC1 lead to myotonia, an inheritable disorder characterized by muscle stiffness and renal salt wasting. CLC2 is highly expressed in the epithelia of several organs including lung, which suggests CLC2 may be a possible therapeutic target for cystic fibrosis. CLC3 expression is particularly abundant in neuronal tissue, while CLC4 expression is evident in skeletal and cardiac muscle as well as brain. Mutations in the gene encoding CLC5 lead to Dent's disease, a renal disorder characterized by proteinuria and hypercalciuria.

Gen-ID: 12728

NCBI Accession: NP_001230691

UniProt: Q9WVD4